Table 1Summary of effects of chronic ethanol treatment on the membrane response to AMPA at 15 DIV
Depolarization
Hyperpolarization
Peak amplitude (mV)
Duration (s)a
Peak amplitude (mV)
Duration (s)a
1 μM AMPA
Control (n=14)
25±2
17±2
3±1
77±11
Chronic ethanol (n=17)
26±2
18±1
3±0.5
76±7
5 μM AMPA
Control (n=16)
33±2
48±4
7±1
119±12
Chronic ethanol (n=19)
34±1
53±4
7±1
127±12
There was no difference between the control and chronic ethanol treatment groups for any of the measurements (P>0.05, unpaired t-test). All values are the mean±S.E.M. and represent combined data from studies performed in the presence and absence of TTX.aThe duration of the depolarization represents the time from AMPA application to recovery to baseline; the duration of the hyperpolarization is taken from the start of the hyperpolarization to when the hyperpolarization recovers to one-half of the maximal hyperpolarization.